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Autosomal dominant

Inheritance - autosomal dominant; Genetics - autosomal dominant

Autosomal dominant is one of several ways that a trait or disorder can be passed down (inherited) through families.

In an autosomal dominant disease, if you inherit the abnormal gene from only one parent, you can get the disease. Often, one of the parents may also have the disease.

Information

Inheriting a disease, condition, or trait depends on the type of chromosome affected (nonsex or sex chromosome). It also depends on whether the trait is dominant or recessive.

A single abnormal gene on one of the first 22 nonsex (autosomal) chromosomes from either parent can cause an autosomal disorder.

Dominant inheritance means an abnormal gene from one parent can cause disease. This happens even when the matching gene from the other parent is normal. The abnormal gene dominates.

This disease can also occur as a new condition in a child when neither parent has the abnormal gene.

A parent with an autosomal dominant condition has a 50% chance of having a child with the condition. This is true for each pregnancy.

It means that each child's risk for the disease does not depend on whether their sibling has the disease.

Children who do not inherit the abnormal gene will not develop or pass on the disease.

If someone is diagnosed with an autosomal dominant disease, their parents should also be tested for the abnormal gene.

Examples of autosomal dominant disorders include Huntington disease and neurofibromatosis type 1.

References

Scott DA, Lee B. Patterns of genetic transmission. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 80.

Wiggs JL. Fundamentals of human genetics. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. Philadelphia, PA: Elsevier; 2014:chap 1.1.

    • Autosomal dominant genes

      Autosomal dominant genes - illustration

      In the case of autosomal dominant genes, a single abnormal gene on one of the autosomal chromosomes (one of the first 22 "non-sex" chromosomes) from either parent can cause the disease. One of the parents will have the disease (since it is dominant) in this mode of inheritance and that person is called the CARRIER. Only one parent must be a carrier in order for the child to inherit the disease.

      Autosomal dominant genes

      illustration

      • Autosomal dominant genes

        Autosomal dominant genes - illustration

        In the case of autosomal dominant genes, a single abnormal gene on one of the autosomal chromosomes (one of the first 22 "non-sex" chromosomes) from either parent can cause the disease. One of the parents will have the disease (since it is dominant) in this mode of inheritance and that person is called the CARRIER. Only one parent must be a carrier in order for the child to inherit the disease.

        Autosomal dominant genes

        illustration

      Review Date: 2/15/2016

      Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

      The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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