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Acetylcholine receptor antibody

Acetylcholine receptor antibody is a protein found in the blood of most people with myasthenia gravis. The antibody affects a chemical that sends signals from nerves to muscles and between nerves in the brain.

This article discusses the blood test for acetylcholine receptor antibody.

How the Test is Performed

A blood sample is needed. Most of the time, blood is drawn from a vein located on the inside of the elbow or the back of the hand.

How to Prepare for the Test

Most of the time you do not need to take special steps before this test.

How the Test will Feel

You may feel slight pain or a sting when the needle is inserted. You may also feel some throbbing at the site after the blood is drawn.

Why the Test is Performed

This test is used to help diagnose myasthenia gravis.

Normal Results

Normally, there is no acetylcholine receptor antibody (or less than 0.05 nmol/L) in the bloodstream.

Note: nmol = nanomole

Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

The example above shows the common measurement for results for these tests. Some laboratories use different measurements or may test different specimens.

What Abnormal Results Mean

An abnormal result means acetylcholine receptor antibody has been detected in your blood. It confirms the diagnosis of myasthenia gravis in people who have symptoms. Nearly half of people with myasthenia gravis that is limited to their eye muscles (ocular myasthenia gravis) have this antibody in their blood.

However, the lack of this antibody does not rule out myasthenia gravis. About 1 in 5 people with myasthenia gravis do not have signs of this antibody in their blood.

References

Meriggioli MN. Sanders DB. Disorders of neuromuscular transmission In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 78.

Vincent A, Evoli A. Disorders of neuromuscular transmission In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 422.

    • Blood test

      Blood test - illustration

      Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.

      Blood test

      illustration

    • Central nervous system and peripheral nervous system

      Central nervous system and peripheral nervous system - illustration

      The central nervous system is comprised of the brain and spinal cord. The peripheral nervous system includes all peripheral nerves.

      Central nervous system and peripheral nervous system

      illustration

      • Blood test

        Blood test - illustration

        Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.

        Blood test

        illustration

      • Central nervous system and peripheral nervous system

        Central nervous system and peripheral nervous system - illustration

        The central nervous system is comprised of the brain and spinal cord. The peripheral nervous system includes all peripheral nerves.

        Central nervous system and peripheral nervous system

        illustration

      Tests for Acetylcholine receptor antibody

       

      Review Date: 6/1/2015

      Reviewed By: Daniel Kantor, MD, Kantor Neurology, Coconut Creek, FL and immediate past president of the Florida Society of Neurology (FSN). Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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